Insulin-like growth factor 2

Insulin-like growth factor 2

IGF2 gene is located on chromosome 11p15.5
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Insulin-like growth factor II receptor-α is a novel stress-inducible contributor to cardiac damage underpinning doxorubicin-induced oxidative stress and perturbed mitochondrial autophagy.

Doxorubicin (DOX) is an anthracycline antibiotic commonly used to treat various types of cancer. However, the therapeutic use is hampered by side effects associated with cumulative dose during treatment. While deregulation of autophagy in the myocardium have been involved in a variety of cardiovascular diseases, the role of autophagy in the remnants of DOX-induced cardiomyopathy debated. Our studies have previously shown that treatment of DOX in a rat animal model that leads to increased expression of novel stress-induced protein insulin-like growth factor II receptor-α (IGF-IIRα) in heart tissue, which worsens cardiac injury by increasing oxidative stress and p53 -mediated mitochondrial dependent apoptosis of heart.

Through this study, we investigate the contribution of IGF-IIRα to dysregulation of autophagy in the liver using both in cell H9c2 vitro (DOX treated, 1 M) and in vivo transgenic mouse model (DOX-treated, 5 mg / kg ip for 6 weeks) overexpressing IGF Special -IIRα in the heart. We found that IGF-IIRα mainly translated into mitochondria, causing an increase in severe mitochondrial oxidative stress exacerbated by DOX treatment.

It is accompanied by a significant disturbance in the mitochondrial membrane potential and increased leakage of cytochrome c, resulting in an increase in cleaved caspase-3 activity. There is a significant change in the phosphorylated AMP-activated protein kinase (p-AMPK), phosphorylated Unc-51 like kinase-1 (p-ULK1), Parkin, PTEN-induced kinase 1 (PINK1), microtubule-associated protein 1 light chain 3 ( LC3), and the P62 protein, which is more severe impaired under the combined effects of IGF-IIRα excess plus DOX.

Finally, LysoTracker Red staining showed that IGF-IIRα excess causes damage to the lysosomes, which was saved by Rapamycin treatment. Taken together, we found that IGF-IIRα leading to mitochondrial oxidative stress, decreased antioxidant levels, impaired mitochondrial membrane potential, and impaired mitochondrial autophagy contributes to DOX-induced cardiomyopathy.

Insulin-like growth factor II receptor-α is a novel stress-inducible contributor to cardiac damage underpinning doxorubicin-induced oxidative stress and perturbed mitochondrial autophagy.
Insulin-like growth factor II receptor-α is a novel stress-inducible contributor to cardiac damage underpinning doxorubicin-induced oxidative stress and perturbed mitochondrial autophagy.

Insulin – like growth factor two regulate the proliferation and differentiation of stromal cells of mice adipose- came through the IGF-1R and IR.

Insulin-like growth factor 2 (IGF2), an essential component of the stem cell niche, has been reported to modulate the proliferation and differentiation of stem cells. Previously, the expression of IGF2 in the network continuously reported for maintaining self-renewal ability of some types of stem cells. Therefore, in this study, we investigated the IGF2 expression in adipose tissue and explore the IGF2 effect on adipose-derived stromal cells (ADSCs) in vitro.

The pattern IGF2 expression in rat adipose tissue is determined by gene expression and protein analysis. IGF2 influence on proliferation, associated stemness marker expression and adipogenic and osteogenic differentiation systematically investigated. Furthermore, antagonists of IGF2 receptor-specific-that is, BMS-754 807 and picropodophyllin-written to explore the underlying signal transduction mechanisms.IGF2 levels displayed a tendency to decrease with age in rat adipose tissue.

After the addition of IGF2, isolated ADSCs displayed a higher proliferation and expression of markers associated stemness NANOG, OCT4 and Sox2 and the potential for greater differentiation to adipocytes and osteoblasts. In addition, both type 1 insulin-like growth factor receptor (IGF-1R) and insulin receptor (IR) participate in the promotion of IGF2-mediated stemness in ADSCs.

IGF1 Receptor Antibody

AF6123 100ul
EUR 280
Description: Human,Mouse,Rat

IGF1 Receptor Antibody

AF6124 100ul
EUR 280
Description: Human,Mouse,Rat

IGF1 Receptor Antibody

DF6046 100ul
EUR 280
Description: Human,Mouse,Rat

IGF1 Receptor Antibody

E38PA1579 100ul
EUR 225
Description: Available in various conjugation types.

IGF1 Receptor Antibody

AF7709-100ul 100ul
EUR 350

IGF1 Receptor Antibody

AF7709-200ul 200ul
EUR 450

IGF1 Receptor Antibody

AF7709-50ul 50ul
EUR 250

IGF1 Receptor Antibody

AF4697-100ul 100ul
EUR 350

IGF1 Receptor Antibody

AF4697-200ul 200ul
EUR 450

IGF1 Receptor Antibody

AF4697-50ul 50ul
EUR 250

IGF1 Receptor Antibody

AF6123-100ul 100ul
EUR 280

IGF1 Receptor Antibody

AF6123-200ul 200ul
EUR 350

IGF1 Receptor Antibody

AF6124-100ul 100ul
EUR 280

IGF1 Receptor Antibody

AF6124-200ul 200ul
EUR 350

IGF1 Receptor Antibody

DF6046-100ul 100ul
EUR 280

IGF1 Receptor Antibody

DF6046-200ul 200ul
EUR 350

IGF1 Receptor Antibody (IGF1R)

F50633-0.08ML 0.08 ml
EUR 140.25
Description: The IGF1 receptor binds insulin-like growth factor with a high affinity and plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. The protein possess tyrosine kinase activity.

IGF1 Receptor Antibody (IGF1R)

F50634-0.08ML 0.08 ml
EUR 140.25
Description: IGF1R is a tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1 receptor is involved in cell growth and survival control. It is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis.

IGF1 Receptor Antibody / IGF1R

R32816 100 ug
EUR 356.15
Description: IGF1R (Insulin-like Growth Factor 1 (IGF-1) Receptor) is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called Insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2. It belongs to the large class of tyrosine kinase receptors. The IGF1R gene is mapped on 15q26.3. IGF-1 plays an important role in growth and continues to have anabolic effects in adults - meaning that it can induce hypertrophy of skeletal muscle and other target tissues. Using a yeast 2-hybrid system, it was identified a regulatory subunit of phosphatidylinositol (PI) 3-kinase, PIK3R3, as a binding partner of IGF1R. Functional interaction between BRCA1 and SP1 in the regulation of the IGF1R gene was studied in Schneider cells, a Drosophila cell line which lacks endogenous SP1. In these cells, BRCA1 suppressed 45% of the SP1-induced trans-activation of the IGF1R promoter. Overexpression of the Grb10-binding fragment of Gigyf1 resulted in a significant increase in Igf1-stimulated Igf1r tyrosine phosphorylation. Like the insulin receptor, the IGF-1 receptor is a receptor tyrosine kinase - meaning it signals by causing the addition of a phosphate molecule on particular tyrosines. IGF-1 activates the Insulin receptor at approximately 0.1x the potency of insulin. Part of this signaling may be via IGF1R-InsulinReceptor heterodimers.

IGF1 Receptor (pY1161) Antibody

E38PA3484 100ul
EUR 225
Description: Available in various conjugation types.

IGF1 Receptor (pY1161) Antibody

E38PA4435 100ul
EUR 225
Description: Available in various conjugation types.

Monoclonal IGF1R / IGF1 Receptor Antibody

AMM01850G 0.05mg
EUR 580.8
Description: A Monoclonal antibody against Human IGF1R / IGF1 Receptor. The antibodies are raised in Mouse. This antibody is applicable in WB and IHC-P, E, Flo

IGF1 Receptor (pY1165/Y1166) Antibody

E38PA1578 100ul
EUR 225
Description: Available in various conjugation types.

Rabbit Polyclonal IGF1 Receptor Antibody

TA309698 100 µl Ask for price

Rabbit Polyclonal IGF1 Receptor Antibody

TA590052 100 µg Ask for price

IGF1 Receptor (IGF1R) mouse polyclonal antibody

MO15074-500 500 µg Ask for price

Polyclonal IGF1 Receptor (IGF1R) Antibody (N-term)

APR05979G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IGF1 Receptor (IGF1R) (N-term). This antibody is tested and proven to work in the following applications:

Polyclonal IGF1 Receptor (IGF1R) Antibody (C-term)

APR05980G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IGF1 Receptor (IGF1R) (C-term). This antibody is tested and proven to work in the following applications:

IGF1 Receptor (IGF1R) rabbit polyclonal antibody, Serum

AP55027SU-N 200 µl Ask for price

Polyclonal IGF1R / IGF1 Receptor Antibody (aa1126-1175)

APR02912G 0.05ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IGF1R / IGF1 Receptor (aa1126-1175). This antibody is tested and proven to work in the following applications:

IGF1 Receptor (IGF1R) rabbit polyclonal antibody, Aff - Purified

AP02620PU-N 100 µg Ask for price

IGF1 Receptor (IGF1R) rabbit polyclonal antibody, Aff - Purified

AP02620PU-S 50 µg Ask for price

IGF1 Receptor (IGF1R) rabbit polyclonal antibody, Aff - Purified

AP02621PU-N 100 µg Ask for price

IGF1 Receptor (IGF1R) rabbit polyclonal antibody, Aff - Purified

AP02621PU-S 50 µg Ask for price

IGF1 Receptor (IGF1R) rabbit polyclonal antibody, Aff - Purified

AP02787PU-N 100 µg Ask for price

IGF1 Receptor (IGF1R) rabbit polyclonal antibody, Aff - Purified

AP02787PU-S 50 µg Ask for price

IGF1 Receptor (IGF1R) rabbit polyclonal antibody, Aff - Purified

AP06177PU-N 100 µg Ask for price

IGF1 Receptor (IGF1R) rabbit polyclonal antibody, Aff - Purified

AP06178PU-N 100 µg Ask for price

IGF1 Receptor (IGF1R) rabbit polyclonal antibody, Aff - Purified

AP08068PU-N 100 µg Ask for price

IGF1 Receptor (IGF1R) rabbit polyclonal antibody, Aff - Purified

AP08068PU-S 50 µg Ask for price

Monoclonal IGF1R / IGF1 Receptor Antibody (clone 1H7), Clone: 1H7

AMM01769G 0.05mg
EUR 580.8
Description: A Monoclonal antibody against Human IGF1R / IGF1 Receptor (clone 1H7). The antibodies are raised in Mouse and are from clone 1H7. This antibody is applicable in WB and IHC-P, Flo

IGF1 Receptor (IGF1R) (N-term) rabbit polyclonal antibody, Purified

AP14361PU-N 400 µl Ask for price

IGF1 Receptor (IGF1R) mouse monoclonal antibody, clone 3C8B1, Ascites

AM06175SU-N 100 µl Ask for price

IGF1 Receptor (IGF1R) mouse monoclonal antibody, clone 3G5C1, Ascites

AM06184SU-N 100 µl Ask for price

IGF1 Receptor (IGF1R) pTyr980 rabbit polyclonal antibody, Aff - Purified

AP20951PU-N 100 µg Ask for price

Rabbit anti-IGF1 Receptor Antibody

YLD4231-100ul 100 ul
EUR 320
Description: Rabbit polyclonal antibody to IGF1 Receptor

Rabbit anti-IGF1 Receptor Antibody

YLD4231-50ul 50 ul
EUR 200
Description: Rabbit polyclonal antibody to IGF1 Receptor

Rabbit anti-IGF1 Receptor Antibody

YLD4232-100ul 100 ul
EUR 320
Description: Rabbit polyclonal antibody to IGF1 Receptor

Rabbit anti-IGF1 Receptor Antibody

YLD4232-50ul 50 ul
EUR 200
Description: Rabbit polyclonal antibody to IGF1 Receptor

Rabbit anti-IGF1 Receptor Antibody

YLD4233-100ul 100 ul
EUR 320
Description: Rabbit polyclonal antibody to IGF1 Receptor

Rabbit anti-IGF1 Receptor Antibody

YLD4233-50ul 50 ul
EUR 200
Description: Rabbit polyclonal antibody to IGF1 Receptor

Rabbit anti-IGF1 Receptor Antibody

DL93679A-100ul 100 ul
EUR 336
Description: Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD221

Rabbit anti-IGF1 Receptor Antibody

DL93679A-50ul 50 ul
EUR 235.2
Description: Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD221

Rabbit anti-IGF1 Receptor Antibody

DL90579A-100ul 100 ul
EUR 342
Description: IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD221; INSR; Insulin receptor; IR; CD220

Rabbit anti-IGF1 Receptor Antibody

DL90579A-50ul 50 ul
EUR 239.4
Description: IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD221; INSR; Insulin receptor; IR; CD220

Rabbit anti-IGF1 Receptor Antibody

DL90580A-100ul 100 ul
EUR 336
Description: Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD221

Rabbit anti-IGF1 Receptor Antibody

DL90580A-50ul 50 ul
EUR 235.2
Description: Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD221

IGF1 Receptor (IGF1R) pTyr1280 rabbit polyclonal antibody, Aff - Purified

AP26038PU-N 100 µg Ask for price

IGF1 Receptor (IGF1R) pTyr1280 rabbit polyclonal antibody, Aff - Purified

AP26038PU-S 50 µg Ask for price

IGF1 Receptor (IGF1R) pTyr1346 rabbit polyclonal antibody, Aff - Purified

AP55741PU-N 100 µg Ask for price

IGF1 Receptor (IGF1R) pTyr1346 rabbit polyclonal antibody, Aff - Purified

AP55741PU-S 50 µg Ask for price

IGF1 Receptor (IGF1R) pTyr1161 rabbit polyclonal antibody, Aff - Purified

AP01610PU-N 100 µg Ask for price

IGF1 Receptor (IGF1R) pTyr1165/1166 rabbit polyclonal antibody, Aff - Purified

AP01611PU-N 100 µg Ask for price

IGF1 Receptor (IGF1R) pTyr1165/1166 rabbit polyclonal antibody, Aff - Purified

AP02386PU-N 100 µg Ask for price

IGF1 Receptor (IGF1R) pTyr1165/1166 rabbit polyclonal antibody, Aff - Purified

AP02386PU-S 50 µg Ask for price

IGF1 Receptor (IGF1R) (alpha chain) mouse monoclonal antibody, clone 1H7, PE

BM2226R 100 Tests Ask for price

IGF1 Receptor (IGF1R) (1264-1367) mouse monoclonal antibody, clone JBW902, Purified

AM20501PU-N 50 µg Ask for price

IGF1 Receptor (IGF1R) (alpha chain) mouse monoclonal antibody, clone 1H7, Purified

BM2226P 200 µg Ask for price

IGF1 Receptor (IGF1R) (alpha chain) mouse monoclonal antibody, clone 1H7, Purified

BM2226PT 25 µg Ask for price

Rabbit anti-IGF1 Receptor (pY1161) Antibody

YLD4228-100ul 100 ul
EUR 320
Description: Rabbit polyclonal antibody to IGF1 Receptor (pY1161)

Rabbit anti-IGF1 Receptor (pY1161) Antibody

YLD4228-50ul 50 ul
EUR 200
Description: Rabbit polyclonal antibody to IGF1 Receptor (pY1161)

Rabbit anti-IGF1 Receptor (pY1161) Antibody

YLD4229-100ul 100 ul
EUR 320
Description: Rabbit polyclonal antibody to IGF1 Receptor (pY1161)

Rabbit anti-IGF1 Receptor (pY1161) Antibody

YLD4229-50ul 50 ul
EUR 200
Description: Rabbit polyclonal antibody to IGF1 Receptor (pY1161)

Rabbit anti-IGF1 Receptor (pY1161) Antibody

DL92484A-100ul 100 ul
EUR 370
Description: IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD221; INSR; Insulin receptor; IR; CD220

Rabbit anti-IGF1 Receptor (pY1161) Antibody

DL92484A-50ul 50 ul
EUR 259
Description: IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD221; INSR; Insulin receptor; IR; CD220

Rabbit anti-IGF1 Receptor (pY1161) Antibody

DL93435A-100ul 100 ul
EUR 350
Description: IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD221; INSR; Insulin receptor; IR; CD220

Rabbit anti-IGF1 Receptor (pY1161) Antibody

DL93435A-50ul 50 ul
EUR 245
Description: IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD221; INSR; Insulin receptor; IR; CD220

Monoclonal IGF1R / IGF1 Receptor Antibody (aa1264-1367, clone JBW902), Clone: JBW902

AMM01789G 0.05mg
EUR 580.8
Description: A Monoclonal antibody against Human IGF1R / IGF1 Receptor (aa1264-1367, clone JBW902). The antibodies are raised in Mouse and are from clone JBW902. This antibody is applicable in WB and IHC-P, IP

IGF1 Receptor (IGF1R) (alpha chain) mouse monoclonal antibody, clone 1H7, Low Endotoxin

BM2226LE 500 µg Ask for price

IGF1 Receptor Rabbit mAb

E2R26881 100ul
EUR 255
Description: Available in various conjugation types.

IGF1 Receptor Rabbit mAb

E2R26882 100ul
EUR 255
Description: Available in various conjugation types.

anti-IGF1 Receptor

YF-PA23965 50 ul
EUR 400.8
Description: Mouse polyclonal to IGF1 Receptor

anti-IGF1 Receptor

YF-PA12619 100 ug
EUR 483.6
Description: Rabbit polyclonal to IGF1 Receptor

Rabbit anti-IGF1 Receptor (pY1165/Y1166) Antibody

YLD4230-100ul 100 ul
EUR 320
Description: Rabbit polyclonal antibody to IGF1 Receptor (pY1165/Y1166)

Rabbit anti-IGF1 Receptor (pY1165/Y1166) Antibody

YLD4230-50ul 50 ul
EUR 200
Description: Rabbit polyclonal antibody to IGF1 Receptor (pY1165/Y1166)

Rabbit anti-IGF1 Receptor (pY1165/Y1166) Antibody

DL90578A-100ul 100 ul
EUR 336
Description: Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD221

Rabbit anti-IGF1 Receptor (pY1165/Y1166) Antibody

DL90578A-50ul 50 ul
EUR 235.2
Description: Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD221

IGF1 Receptor (IGF1R) pTyr1316, (incl. pos. control) mouse monoclonal antibody, clone 2B9, Purified

AM00071PU-N 100 µg Ask for price

IGF1 Receptor (IGF1R) (C-term) (incl. pos. control) mouse monoclonal antibody, clone 7G11, Biotin

AM00072BT-N 100 µg Ask for price

IGF1 Receptor (IGF1R) (C-term) (incl. pos. control) mouse monoclonal antibody, clone 7G11, Purified

AM00072PU-N 100 µg Ask for price

Phospho-IGF1 Receptor (Tyr980) Antibody

AF8118 100ul
EUR 350
Description: Human,Mouse

Phospho-IGF1 Receptor (Tyr980) Antibody

AF8118-100ul 100ul
EUR 350

Phospho-IGF1 Receptor (Tyr980) Antibody

AF8118-200ul 200ul
EUR 450

Phospho-IGF1 Receptor (Thr1163) Antibody

AF7209 100ul
EUR 350
Description: Human,Mouse,Rat

Phospho-IGF1 Receptor (Tyr1346) Antibody

AF3124 100ul
EUR 280
Description: Human,Mouse,Rat

Phospho-IGF1 Receptor (Thr1163) Antibody

AF7209-100ul 100ul
EUR 350

Phospho-IGF1 Receptor (Thr1163) Antibody

AF7209-200ul 200ul
EUR 450

Phospho-IGF1 Receptor (Tyr1346) Antibody

AF3124-100ul 100ul
EUR 280

Phospho-IGF1 Receptor (Tyr1346) Antibody

AF3124-200ul 200ul
EUR 350

Anti-Mannose 6 Phosphate Receptor/Igf2r Antibody

A00951-1 100ug/vial
EUR 400.8

IGF1 Receptor (IGF1R) (N-term) Rabbit pAb

E2616363 100ul
EUR 225
Description: Available in various conjugation types.

IGF1 Receptor (IGF1R) (C-term) Rabbit pAb

E2620068 100ul
EUR 225
Description: Available in various conjugation types.

IGF1R/Insulin Receptor Antibody

AF6125 100ul
EUR 280
Description: Human,Mouse,Rat

IGF1R/Insulin Receptor Antibody

AF6125-100ul 100ul
EUR 280

IGF1R/Insulin Receptor Antibody

AF6125-200ul 200ul
EUR 350

anti- IGF1 antibody

FNab09936 100µg
EUR 658.5
Description: Antibody raised against IGF1

anti- IGF1 antibody

LSMab09936 100 ug
EUR 463.2

Phospho-IGF1 Receptor (Tyr1131/Tyr1146) Antibody

AF4397 100ul
EUR 350
Description: Human,Mouse,Rat,Pig

Phospho-IGF1 Receptor (Tyr1165/Tyr1166) Antibody

AF3123 100ul
EUR 280
Description: Human,Mouse,Rat

Phospho-IGF1 Receptor (Tyr1131/Tyr1146) Antibody

AF4397-100ul 100ul
EUR 350

Phospho-IGF1 Receptor (Tyr1131/Tyr1146) Antibody

AF4397-200ul 200ul
EUR 450

Phospho-IGF1 Receptor (Tyr1165/Tyr1166) Antibody

AF3123-100ul 100ul
EUR 280

Phospho-IGF1 Receptor (Tyr1165/Tyr1166) Antibody

AF3123-200ul 200ul
EUR 350

IGF-I Receptor/Insulin Receptor Antibody

E11-184697 100ug/100ul
EUR 225
Description: Available in various conjugation types.

Anti-Mannose 6 Phosphate Receptor (Cation independent)/IGF2R Antibody

A00951 100ug/vial
EUR 400.8

Anti-Mannose 6 Phosphate Receptor (Cation independent)/IGF2R Antibody

PA2182 100ug/vial
EUR 400.8

IGF-I Receptor β Antibody

E90073 100ug
EUR 255
Description: Available in various conjugation types.

IGF-I Receptor β Antibody

E90243 100ul
EUR 255
Description: Available in various conjugation types.

anti-IgE receptor antibody/ Rat anti- IgE receptor antibody ELIS

ELA-E0378r 96 Tests
EUR 1063.2

Insulin Like Growth Factor 2 Receptor (IGF2R) Antibody

20-abx104018
  • EUR 493.20
  • EUR 159.60
  • EUR 1378.80
  • EUR 678.00
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Insulin Like Growth Factor 2 Receptor (IGF2R) Antibody

20-abx104019
  • EUR 510.00
  • EUR 159.60
  • EUR 1412.40
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Insulin Like Growth Factor 2 Receptor (IGF2R) Antibody

20-abx104020
  • EUR 526.80
  • EUR 159.60
  • EUR 1479.60
  • EUR 710.40
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

20-abx172913
  • EUR 393.60
  • EUR 978.00
  • EUR 510.00
  • EUR 184.80
  • EUR 309.60
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

20-abx172914
  • EUR 1045.20
  • EUR 543.60
  • 1 mg
  • 200 ug

Insulin Like Growth Factor 2 Receptor (IGF2R) Antibody

20-abx172921
  • EUR 978.00
  • EUR 510.00
  • 1 mg
  • 200 ug

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

20-abx176960
  • EUR 1412.40
  • EUR 693.60
  • 1 mg
  • 200 ug

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

20-abx176961
  • EUR 1412.40
  • EUR 693.60
  • 1 mg
  • 200 ug

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

20-abx176962
  • EUR 1496.40
  • EUR 710.40
  • 1 mg
  • 200 ug

Insulin Like Growth Factor 2 Receptor (IGF2R) Antibody

20-abx212994
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Insulin Like Growth Factor 2 Receptor (IGF2R) Antibody

20-abx211941
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Insulin Like Growth Factor 2 Receptor (IGF2R) Antibody

20-abx325337
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

abx331540-100ul 100 ul
EUR 510

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

abx331990-100ul 100 ul
EUR 510

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

abx332030-100ul 100 ul
EUR 510

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

abx332058-100ul 100 ul
EUR 510

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

abx332126-100ul 100 ul
EUR 510

Insulin Like Growth Factor 2 Receptor (IGF2R) Antibody

20-abx326743
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

20-abx327081
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

20-abx113163
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Insulin Like Growth Factor 2 Receptor (IGF2R) Antibody

20-abx113166
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

abx016028-100ul 100 ul
EUR 493.2

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

abx033572-400ul 400 ul
EUR 627.6

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

abx033572-80l 80 µl
EUR 343.2

Insulin Like Growth Factor 2 Receptor (IGF2R) Antibody

abx038272-100ug 100 ug
EUR 469.2

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

20-abx128804
  • EUR 493.20
  • EUR 159.60
  • EUR 1378.80
  • EUR 678.00
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Insulin Like Growth Factor 2 Receptor (IGF2R) Antibody

20-abx125346
  • EUR 710.40
  • EUR 1028.40
  • EUR 493.20
  • 100 ul
  • 200 ul
  • 50 ul

Insulin Like Growth Factor 2 Receptor (IGF2R) Antibody

20-abx123245
  • EUR 493.20
  • EUR 710.40
  • 100 ul
  • 200 ul

Insulin Like Growth Factor 2 Receptor (IGF2R) Antibody

20-abx323556
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

20-abx327744
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

20-abx328731
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

20-abx009124
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

20-abx009125
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

20-abx000628
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

abx010963-100ul 100 ul
EUR 493.2

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

20-abx012900
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

20-abx306436
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

IGF1R Antibody / Insulin like growth factor 1 receptor

F54940-0.08ML 0.08 ml
EUR 140.25
Description: The IGF1 receptor binds insulin-like growth factor with a high affinity and plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. The protein possess tyrosine kinase activity.

IGF1R Antibody / Insulin like growth factor 1 receptor

F54940-0.4ML 0.4 ml
EUR 322.15
Description: The IGF1 receptor binds insulin-like growth factor with a high affinity and plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. The protein possess tyrosine kinase activity.

IGF1R Antibody / Insulin like growth factor 1 receptor

V8864-100UG 100ug
EUR 349.3
Description: Receptor tyrosine kinases (RTKs) are transmembrane molecular scaffolds that influence cellular processes including the cell cycle, cell migration, cell metabolism, cell survival, proliferation and differentiation. Insulin-like growth factor-I receptor (IGF-IR) is an RTK that stimulates growth in many different cell types, blocks apoptosis, acts as an intermediate of many growth hormone responses and may stimulate the growth of some types of cancer. The IGF-IR cognate ligand Insulin-like growth factor-I (IGF-I) promotes association of IGF-IR with Shc, GRB2 and Sos 1, which initiates Ras and ERK kinase cascades, thereby modifying transcription factor activity, such as activation of the Elk transcription factors. The modular phosphotyrosine binding (PTB) domains of Insulin receptor substrate (IRS)-1 and -2 can associate with active IGF-IR and initiate phosphatidylinositol 3-kinase-dependent downstream signals. The human IGF-IR gene maps to chromosome 15q26.3 and encodes a 1,376 amino acid precursor protein that cleaves into subunits. The human IGF-IIR gene maps to chromosome 6q26 and encodes a 2,491 amino acid transmembrane protein.

IGF1R Antibody / Insulin like growth factor 1 receptor

V8864-20UG 20ug
EUR 153.3
Description: Receptor tyrosine kinases (RTKs) are transmembrane molecular scaffolds that influence cellular processes including the cell cycle, cell migration, cell metabolism, cell survival, proliferation and differentiation. Insulin-like growth factor-I receptor (IGF-IR) is an RTK that stimulates growth in many different cell types, blocks apoptosis, acts as an intermediate of many growth hormone responses and may stimulate the growth of some types of cancer. The IGF-IR cognate ligand Insulin-like growth factor-I (IGF-I) promotes association of IGF-IR with Shc, GRB2 and Sos 1, which initiates Ras and ERK kinase cascades, thereby modifying transcription factor activity, such as activation of the Elk transcription factors. The modular phosphotyrosine binding (PTB) domains of Insulin receptor substrate (IRS)-1 and -2 can associate with active IGF-IR and initiate phosphatidylinositol 3-kinase-dependent downstream signals. The human IGF-IR gene maps to chromosome 15q26.3 and encodes a 1,376 amino acid precursor protein that cleaves into subunits. The human IGF-IIR gene maps to chromosome 6q26 and encodes a 2,491 amino acid transmembrane protein.

IGF1R Antibody / Insulin like growth factor 1 receptor

V8864SAF-100UG 100ug
EUR 349.3
Description: Receptor tyrosine kinases (RTKs) are transmembrane molecular scaffolds that influence cellular processes including the cell cycle, cell migration, cell metabolism, cell survival, proliferation and differentiation. Insulin-like growth factor-I receptor (IGF-IR) is an RTK that stimulates growth in many different cell types, blocks apoptosis, acts as an intermediate of many growth hormone responses and may stimulate the growth of some types of cancer. The IGF-IR cognate ligand Insulin-like growth factor-I (IGF-I) promotes association of IGF-IR with Shc, GRB2 and Sos 1, which initiates Ras and ERK kinase cascades, thereby modifying transcription factor activity, such as activation of the Elk transcription factors. The modular phosphotyrosine binding (PTB) domains of Insulin receptor substrate (IRS)-1 and -2 can associate with active IGF-IR and initiate phosphatidylinositol 3-kinase-dependent downstream signals. The human IGF-IR gene maps to chromosome 15q26.3 and encodes a 1,376 amino acid precursor protein that cleaves into subunits. The human IGF-IIR gene maps to chromosome 6q26 and encodes a 2,491 amino acid transmembrane protein.

Human Type I IGF receptor 16-13 (62 - 184) monoclonal antibody

MAC1 200 µg
EUR 358.8

Human Type I IGF receptor 24-55 (440 - 586) monoclonal antibody

MAD1 200 µg
EUR 358.8

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody (KLH)

20-abx133044
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody (RPE)

abx414062-100tests 100 tests
EUR 710.4

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody (HRP)

20-abx306437
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody Pair

abx117571-1pair5x96wellplates 1 pair (5x96 well plates)
EUR 1212

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody (FITC)

20-abx306438
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Human anti-IgE receptor antibody(anti-IgE receptor antibody)ELISA Kit

YLA0043HU-48T 48T
EUR 435

Human anti-IgE receptor antibody(anti-IgE receptor antibody)ELISA Kit

YLA0043HU-96T 96T
EUR 562.5

Insulin Like Growth Factor 1 Receptor (IGF1R) (pY1165 / 1166) Antibody

20-abx119382
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Insulin Like Growth Factor 1 Receptor (IGF1R) (pY1161) Antibody

20-abx134358
  • EUR 376.80
  • EUR 560.40
  • EUR 243.60
  • 100 ul
  • 200 ul
  • 30 ul

Insulin Like Growth Factor 1 Receptor (IGF1R) (pY1161) Antibody

20-abx133041
  • EUR 376.80
  • EUR 560.40
  • EUR 243.60
  • 100 ul
  • 200 ul
  • 30 ul

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody (Biotin)

20-abx306439
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

IGF-I Receptor (Phospho-Thr1163) Antibody

13068-100ul 100ul
EUR 302.4

IGF-I Receptor (Phospho-Thr1163) Antibody

13068-50ul 50ul
EUR 224.4

Human Type I IGF receptor 26-3 (283 - 440 or 586 - 908) monoclonal antibody

MAF1 200 µg
EUR 358.8

IGF1 Antibody

20-abx326449
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

IGF1 antibody

10-I16A 100 ug
EUR 688.8
Description: Mouse monoclonal IGF1 antibody

Our findings show that IGF2 can improve stemness of rat ADSCs through IGF-1R and IR and can highlight an effective method for the expansion of ADSCs for clinical applications.