Roles of insulin-like growth factor II in regulating female reproductive physiology.
by Kayla
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The number of growth factors involved in female fertility have been studied extensively, but a reluctance to add an important growth factor in the culture medium has been progress in optimizing the growth and implantation of the embryo proceeds, a situation which has ultimately led to reduced pregnancy outcomes is limited. Insulin-like growth factor II (IGF-II) is the most complicated of all the relevant regulated reproductive marked growth factor known to date, and may be the dominant growth factor in human ovarian follicle.
This review aims to briefly summarize what is known about the role of IGF-II in follicle development, maturation of oocytes, embryo development, the successful implantation, placentation, fetal growth, and reduce apoptosis of cells of the placenta, and this strategy is that the growth factor use in the culture system to improve potential development of oocytes and embryos in different species.
Synthesize knowledge about the physiological role of IGF-II in follicle development, oocyte maturation and early development of the embryo must, on the one hand, to deepen our understanding of the overall beneficial effects of potential growth factor in women’s reproductive and on the other hand supports the development (optimization) of results better for assisted reproductive technology.
Roles of insulin-like growth factor II in regulating female reproductive physiology.
Reversibility Acute Kidney Injury in ICU Medical Patients: Predictability urinary performance Tissue Inhibitor of Metalloproteinase-
two x Insulin -As Growth Factor -binding Protein 7 and renal Resistive Index. and urinary biomarkers of renal Doppler sonography are considered as a promising tool to distinguish transient from persistent acute kidney injury. Performance urinary biomarkers, tissue inhibitor of metalloproteinase-2 x insulin-like growth factor-binding protein 7 and renal resistive index to predict acute kidney injury persistent showed conflicting results.
Our aim was to evaluate the performance of tissue inhibitor of metalloproteinase-2 x insulin-like growth factor-binding protein 7 and renal resistive index in predicting the reversibility of acute kidney injury in critically ill patients.Prospective observational study.Twenty-bed medical ICU in a university hospital patients injury.None.Renal .Consecutive with acute renal resistive index measured within 12 hours after admission, and bladder tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein 7 was measured at H0, H6, H12, and H24.
Reversibility of kidney dysfunction was evaluated on day 3. Receiver operating characteristic curves were plotted to evaluate the diagnostic performance of renal resistive index and tissue inhibitor of metalloproteinase-2 x insulin-like growth factor-binding protein 7 to predict acute kidney injury persistent. Overall, 100 patients were included in the 50 with persistent acute kidney injury.
Renal resistive index was higher in the group of persistent renal acute injury. urinary tissue inhibitor of metalloproteinase-2 x insulin-like growth factor-binding protein 7 did not differ significantly at any time between the two groups. Performance tissue inhibitor of metalloproteinase-2 x insulin-like growth factor-binding protein 7 was poor with each area under the receiver operating characteristic curve of 0.57 (95% CI, 0.45 to 0.68), 0.58 ( 95% CI, -0.69 to 0.47), 0.61 (95% CI, 0.50 to .72), and 0.57 (95% CI, 0.46 to 0.68) in H0, H6, H12, and H24.
Description: A polyclonal antibody against IGF1. Recognizes IGF1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/10000
Description: A polyclonal antibody against IGF1. Recognizes IGF1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:200-1:500
Description: A polyclonal antibody against IGF1. Recognizes IGF1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:25-1:100
Description: A polyclonal antibody against IGF1. Recognizes IGF1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200
Description: A polyclonal antibody against IGF1. Recognizes IGF1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200
Description: The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.
Description: The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.
Description: The IGF1 receptor binds insulin-like growth factor with a high affinity and plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. The protein possess tyrosine kinase activity.
Description: IGF1R is a tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1 receptor is involved in cell growth and survival control. It is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis.
Description: IGF1R (Insulin-like Growth Factor 1 (IGF-1) Receptor) is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called Insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2. It belongs to the large class of tyrosine kinase receptors. The IGF1R gene is mapped on 15q26.3. IGF-1 plays an important role in growth and continues to have anabolic effects in adults - meaning that it can induce hypertrophy of skeletal muscle and other target tissues. Using a yeast 2-hybrid system, it was identified a regulatory subunit of phosphatidylinositol (PI) 3-kinase, PIK3R3, as a binding partner of IGF1R. Functional interaction between BRCA1 and SP1 in the regulation of the IGF1R gene was studied in Schneider cells, a Drosophila cell line which lacks endogenous SP1. In these cells, BRCA1 suppressed 45% of the SP1-induced trans-activation of the IGF1R promoter. Overexpression of the Grb10-binding fragment of Gigyf1 resulted in a significant increase in Igf1-stimulated Igf1r tyrosine phosphorylation. Like the insulin receptor, the IGF-1 receptor is a receptor tyrosine kinase - meaning it signals by causing the addition of a phosphate molecule on particular tyrosines. IGF-1 activates the Insulin receptor at approximately 0.1x the potency of insulin. Part of this signaling may be via IGF1R-InsulinReceptor heterodimers.
Description: A polyclonal antibody against IGF1. Recognizes IGF1 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA
Description: A polyclonal antibody against IGF1. Recognizes IGF1 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA
Description: A polyclonal antibody against IGF1. Recognizes IGF1 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA
Description: The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein.
Description: The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein.
Description: The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein.
Description: A Monoclonal antibody against Human IGF1R / IGF1 Receptor. The antibodies are raised in Mouse. This antibody is applicable in WB and IHC-P, E, Flo
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human IGF1 (internal region). This antibody is tested and proven to work in the following applications:
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IGF1 Receptor (IGF1R) (N-term). This antibody is tested and proven to work in the following applications:
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IGF1 Receptor (IGF1R) (C-term). This antibody is tested and proven to work in the following applications:
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IGF1R / IGF1 Receptor (aa1126-1175). This antibody is tested and proven to work in the following applications:
Insulin Like Growth Factor 1 (IGF1) Antibody (KLH)
Description: A Monoclonal antibody against Human IGF1R / IGF1 Receptor (clone 1H7). The antibodies are raised in Mouse and are from clone 1H7. This antibody is applicable in WB and IHC-P, Flo
Area under the receiver operating characteristic curve for renal resistive index was 0.93 (95% CI, 0.89 to 0.98). An index greater than or equal resistive kidney with acute kidney injury 0.685 persistent predict with 78% (95% CI, 64-88%) sensitivity and 90% (95% CI, 78-97%) specificity.
