BACKGROUND The purpose of this study was to explore the effects of dexmedetomidine (DEX) -mediated insulin-like growth factor 2 (IGF2) signaling pathway in immune functions and cancer cell invasion and migration in mice with ovarian cancer. MATERIALS AND METHODS Forty mice with ovarian cancer were divided into 4 groups: the model group and low dose (0.2 mg / kg / h DEX), medium dose (1.0 ug / kg / h DEX), and high dose ( 5.0 mg / kg / h DEX) DEX group. In addition, 10 Fischer344 rats selected as normal group.

Human NUTU 19 poorly differentiated epithelial ovarian cancer cells were divided into 4 groups: empty and low-dose, medium-dose and high-dose DEX NUTU-19 group. RESULTS Compared with normal group, other groups serum interleukin (IL) -2 and interferon gamma (INF-γ) levels, CD4⁺ and CD8⁺ percentages, ratios CD4⁺ / CD8⁺, and spleen lymphocyte transformation rate decreases, and the alpha serum tumor necrosis factor (TNF-alpha) levels, IGF2, insulin-like growth factor 1 receptor (IGF1R), insulin receptor substrate 1 (IRS1) mRNA and protein expression in ovarian tissue increased (all P <0.05).

Results in the DEX group compared with the model group are the opposite of those in the control group compared with the normal group (all P <0.05). Compared with blank group, other groups proliferation, invasion, and migration of ovarian cancer cells reduced significantly (all P <0.05). Compared with low doses of DEX NUTU-19 groups, in high doses of DEX-19 group NUTU invasion and migration of ovarian cancer cells weakened significantly (both P <0.05).

Conclusion A certain dose DEX can effectively inhibit the activation of signaling pathways IGF2 to enhance the immune function of mice with ovarian cancer, inhibits invasion and migration of ovarian cancer cells.

Effect of Dexmedetomidine-Mediated <em>Insulin</em>-<em>Like</em> <em>Growth</em> <em>Factor</em> <em>2</em> (IGF<em>2</em>) Signal Pathway on Immune Function and Invasion and Migration of Cancer Cells in Rats with Ovarian Cancer.
Effect of Dexmedetomidine-Mediated InsulinLike Growth Factor 2 (IGF2) Signal Pathway on Immune Function and Invasion and Migration of Cancer Cells in Rats with Ovarian Cancer.

Insulin-like growth factor II mRNA binding protein 3 promotes cell proliferation, migration and invasion in human glioblastoma.

Background / Purpose: Recently, insulin-like growth factor-binding protein mRNA 3 (IMP3) has been reported to be involved in tumorigenesis. We aim to study the expression and role of IMP3 in human glioblastoma. Methods: We analyzed the expression of IMP3 in 70 cases of glioma tissue, normal brain tissue and 5 of cell lines using western blot. Immunohistochemistry (IHC) was used to evaluate the expression and distribution of IMP3 in glioma tissue. colony formation, wound healing, migration and invasion tests and tumorigenesis in nude mice were used to explore the IMP3 function in vitro and in vivo.

The epithelial-mesenchymal transition (EMT) -related biomarkers detected by Western blot. Results: We found that the expression levels of IMP3 was significantly higher in glioma tissue than that in normal brain tissue and glioma associated with the class. In-vitro tests revealed that excessive IMP3 was significantly induced cell proliferation, migration, and invasion. Mechanically, IMP3 over-expression downregulated the expression of E-cadherin, but upregulated the expression of N-cadherin, vimentin, snails, slugs and MMP9.

However, inhibition of oncogenic effects IMP3 disorders. In vivo assay also showed that silencing of IMP3 inhibit tumor growth and increased survival of tumor-bearing nude mice xenograft. Conclusion: IMP3 can promote cell proliferation, migration and invasion by inducing EMT in glioblastoma. Thus, targeting the pathway IMP3 may be a new way to treat patients with glioblastoma.Schizophrenia associated with abnormal neural development of the brain, the IGF-2 (insulin-like growth factor-2) had a major impact.

IGF1 Receptor Antibody

AF6123 100ul
EUR 280
Description: Human,Mouse,Rat

IGF1 Receptor Antibody

AF6124 100ul
EUR 280
Description: Human,Mouse,Rat

IGF1 Receptor Antibody

DF6046 100ul
EUR 280
Description: Human,Mouse,Rat

IGF1 Receptor Antibody

E38PA1579 100ul
EUR 225
Description: Available in various conjugation types.

IGF1 Receptor Antibody

AF7709-100ul 100ul
EUR 350

IGF1 Receptor Antibody

AF7709-200ul 200ul
EUR 450

IGF1 Receptor Antibody

AF7709-50ul 50ul
EUR 250

IGF1 Receptor Antibody

AF4697-100ul 100ul
EUR 350

IGF1 Receptor Antibody

AF4697-200ul 200ul
EUR 450

IGF1 Receptor Antibody

AF4697-50ul 50ul
EUR 250

IGF1 Receptor Antibody

AF6123-100ul 100ul
EUR 280

IGF1 Receptor Antibody

AF6123-200ul 200ul
EUR 350

IGF1 Receptor Antibody

AF6124-100ul 100ul
EUR 280

IGF1 Receptor Antibody

AF6124-200ul 200ul
EUR 350

IGF1 Receptor Antibody

DF6046-100ul 100ul
EUR 280

IGF1 Receptor Antibody

DF6046-200ul 200ul
EUR 350

Anti-IGF1 Receptor/Igf1r Antibody

A00070 100ug/vial
EUR 400.8

Anti-IGF1 Receptor/IGF1R Antibody

PA1746 100ug/vial
EUR 400.8

IGF1 Receptor Antibody (IGF1R)

F50633-0.08ML 0.08 ml
EUR 140.25
Description: The IGF1 receptor binds insulin-like growth factor with a high affinity and plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. The protein possess tyrosine kinase activity.

IGF1 Receptor Antibody (IGF1R)

F50634-0.08ML 0.08 ml
EUR 140.25
Description: IGF1R is a tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1 receptor is involved in cell growth and survival control. It is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis.

IGF1 Receptor Antibody / IGF1R

R32816 100 ug
EUR 356.15
Description: IGF1R (Insulin-like Growth Factor 1 (IGF-1) Receptor) is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called Insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2. It belongs to the large class of tyrosine kinase receptors. The IGF1R gene is mapped on 15q26.3. IGF-1 plays an important role in growth and continues to have anabolic effects in adults - meaning that it can induce hypertrophy of skeletal muscle and other target tissues. Using a yeast 2-hybrid system, it was identified a regulatory subunit of phosphatidylinositol (PI) 3-kinase, PIK3R3, as a binding partner of IGF1R. Functional interaction between BRCA1 and SP1 in the regulation of the IGF1R gene was studied in Schneider cells, a Drosophila cell line which lacks endogenous SP1. In these cells, BRCA1 suppressed 45% of the SP1-induced trans-activation of the IGF1R promoter. Overexpression of the Grb10-binding fragment of Gigyf1 resulted in a significant increase in Igf1-stimulated Igf1r tyrosine phosphorylation. Like the insulin receptor, the IGF-1 receptor is a receptor tyrosine kinase - meaning it signals by causing the addition of a phosphate molecule on particular tyrosines. IGF-1 activates the Insulin receptor at approximately 0.1x the potency of insulin. Part of this signaling may be via IGF1R-InsulinReceptor heterodimers.

IGF1 Receptor (pY1161) Antibody

E38PA3484 100ul
EUR 225
Description: Available in various conjugation types.

IGF1 Receptor (pY1161) Antibody

E38PA4435 100ul
EUR 225
Description: Available in various conjugation types.

Monoclonal IGF1R / IGF1 Receptor Antibody

AMM01850G 0.05mg
EUR 580.8
Description: A Monoclonal antibody against Human IGF1R / IGF1 Receptor. The antibodies are raised in Mouse. This antibody is applicable in WB and IHC-P, E, Flo

IGF1 Receptor (pY1165/Y1166) Antibody

E38PA1578 100ul
EUR 225
Description: Available in various conjugation types.

Polyclonal IGF1R / IGF1 Receptor Antibody (aa1126-1175)

APR02912G 0.05ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IGF1R / IGF1 Receptor (aa1126-1175). This antibody is tested and proven to work in the following applications:

Polyclonal IGF1 Receptor (IGF1R) Antibody (N-term)

APR05979G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IGF1 Receptor (IGF1R) (N-term). This antibody is tested and proven to work in the following applications:

Polyclonal IGF1 Receptor (IGF1R) Antibody (C-term)

APR05980G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IGF1 Receptor (IGF1R) (C-term). This antibody is tested and proven to work in the following applications:

Monoclonal IGF1R / IGF1 Receptor Antibody (clone 1H7), Clone: 1H7

AMM01769G 0.05mg
EUR 580.8
Description: A Monoclonal antibody against Human IGF1R / IGF1 Receptor (clone 1H7). The antibodies are raised in Mouse and are from clone 1H7. This antibody is applicable in WB and IHC-P, Flo

Rabbit anti-IGF1 Receptor Antibody

YLD4231-100ul 100 ul
EUR 320
Description: Rabbit polyclonal antibody to IGF1 Receptor

Rabbit anti-IGF1 Receptor Antibody

YLD4231-50ul 50 ul
EUR 200
Description: Rabbit polyclonal antibody to IGF1 Receptor

Rabbit anti-IGF1 Receptor Antibody

YLD4232-100ul 100 ul
EUR 320
Description: Rabbit polyclonal antibody to IGF1 Receptor

Rabbit anti-IGF1 Receptor Antibody

YLD4232-50ul 50 ul
EUR 200
Description: Rabbit polyclonal antibody to IGF1 Receptor

Rabbit anti-IGF1 Receptor Antibody

YLD4233-100ul 100 ul
EUR 320
Description: Rabbit polyclonal antibody to IGF1 Receptor

Rabbit anti-IGF1 Receptor Antibody

YLD4233-50ul 50 ul
EUR 200
Description: Rabbit polyclonal antibody to IGF1 Receptor

Rabbit anti-IGF1 Receptor Antibody

DL93679A-100ul 100 ul
EUR 336
Description: Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD221

Rabbit anti-IGF1 Receptor Antibody

DL93679A-50ul 50 ul
EUR 235.2
Description: Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD221

Rabbit anti-IGF1 Receptor Antibody

DL90579A-100ul 100 ul
EUR 342
Description: IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD221; INSR; Insulin receptor; IR; CD220

Rabbit anti-IGF1 Receptor Antibody

DL90579A-50ul 50 ul
EUR 239.4
Description: IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD221; INSR; Insulin receptor; IR; CD220

Rabbit anti-IGF1 Receptor Antibody

DL90580A-100ul 100 ul
EUR 336
Description: Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD221

Rabbit anti-IGF1 Receptor Antibody

DL90580A-50ul 50 ul
EUR 235.2
Description: Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD221

Monoclonal IGF1R / IGF1 Receptor Antibody (aa1264-1367, clone JBW902), Clone: JBW902

AMM01789G 0.05mg
EUR 580.8
Description: A Monoclonal antibody against Human IGF1R / IGF1 Receptor (aa1264-1367, clone JBW902). The antibodies are raised in Mouse and are from clone JBW902. This antibody is applicable in WB and IHC-P, IP

IGF1 Receptor Rabbit mAb

E2R26881 100ul
EUR 255
Description: Available in various conjugation types.

IGF1 Receptor Rabbit mAb

E2R26882 100ul
EUR 255
Description: Available in various conjugation types.

Rabbit anti-IGF1 Receptor (pY1161) Antibody

YLD4228-100ul 100 ul
EUR 320
Description: Rabbit polyclonal antibody to IGF1 Receptor (pY1161)

Rabbit anti-IGF1 Receptor (pY1161) Antibody

YLD4228-50ul 50 ul
EUR 200
Description: Rabbit polyclonal antibody to IGF1 Receptor (pY1161)

Rabbit anti-IGF1 Receptor (pY1161) Antibody

YLD4229-100ul 100 ul
EUR 320
Description: Rabbit polyclonal antibody to IGF1 Receptor (pY1161)

Rabbit anti-IGF1 Receptor (pY1161) Antibody

YLD4229-50ul 50 ul
EUR 200
Description: Rabbit polyclonal antibody to IGF1 Receptor (pY1161)

Rabbit anti-IGF1 Receptor (pY1161) Antibody

DL92484A-100ul 100 ul
EUR 370
Description: IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD221; INSR; Insulin receptor; IR; CD220

Rabbit anti-IGF1 Receptor (pY1161) Antibody

DL92484A-50ul 50 ul
EUR 259
Description: IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD221; INSR; Insulin receptor; IR; CD220

Rabbit anti-IGF1 Receptor (pY1161) Antibody

DL93435A-100ul 100 ul
EUR 350
Description: IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD221; INSR; Insulin receptor; IR; CD220

Rabbit anti-IGF1 Receptor (pY1161) Antibody

DL93435A-50ul 50 ul
EUR 245
Description: IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD221; INSR; Insulin receptor; IR; CD220

anti-IGF1 Receptor

YF-PA23965 50 ul
EUR 400.8
Description: Mouse polyclonal to IGF1 Receptor

anti-IGF1 Receptor

YF-PA12619 100 ug
EUR 483.6
Description: Rabbit polyclonal to IGF1 Receptor

Rabbit anti-IGF1 Receptor (pY1165/Y1166) Antibody

YLD4230-100ul 100 ul
EUR 320
Description: Rabbit polyclonal antibody to IGF1 Receptor (pY1165/Y1166)

Rabbit anti-IGF1 Receptor (pY1165/Y1166) Antibody

YLD4230-50ul 50 ul
EUR 200
Description: Rabbit polyclonal antibody to IGF1 Receptor (pY1165/Y1166)

Rabbit anti-IGF1 Receptor (pY1165/Y1166) Antibody

DL90578A-100ul 100 ul
EUR 336
Description: Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD221

Rabbit anti-IGF1 Receptor (pY1165/Y1166) Antibody

DL90578A-50ul 50 ul
EUR 235.2
Description: Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD221

Phospho-IGF1 Receptor (Tyr980) Antibody

AF8118 100ul
EUR 350
Description: Human,Mouse

Phospho-IGF1 Receptor (Tyr980) Antibody

AF8118-100ul 100ul
EUR 350

Phospho-IGF1 Receptor (Tyr980) Antibody

AF8118-200ul 200ul
EUR 450

Phospho-IGF1 Receptor (Thr1163) Antibody

AF7209 100ul
EUR 350
Description: Human,Mouse,Rat

Phospho-IGF1 Receptor (Tyr1346) Antibody

AF3124 100ul
EUR 280
Description: Human,Mouse,Rat

Phospho-IGF1 Receptor (Thr1163) Antibody

AF7209-100ul 100ul
EUR 350

Phospho-IGF1 Receptor (Thr1163) Antibody

AF7209-200ul 200ul
EUR 450

Phospho-IGF1 Receptor (Tyr1346) Antibody

AF3124-100ul 100ul
EUR 280

Phospho-IGF1 Receptor (Tyr1346) Antibody

AF3124-200ul 200ul
EUR 350

IGF1R/Insulin Receptor Antibody

AF6125 100ul
EUR 280
Description: Human,Mouse,Rat

IGF1R/Insulin Receptor Antibody

AF6125-100ul 100ul
EUR 280

IGF1R/Insulin Receptor Antibody

AF6125-200ul 200ul
EUR 350

Anti-Mannose 6 Phosphate Receptor/Igf2r Antibody

A00951-1 100ug/vial
EUR 400.8

IGF1 Receptor (IGF1R) (N-term) Rabbit pAb

E2616363 100ul
EUR 225
Description: Available in various conjugation types.

IGF1 Receptor (IGF1R) (C-term) Rabbit pAb

E2620068 100ul
EUR 225
Description: Available in various conjugation types.

IGF-I Receptor/Insulin Receptor Antibody

E11-184697 100ug/100ul
EUR 225
Description: Available in various conjugation types.

IGF-I Receptor β Antibody

E90073 100ug
EUR 255
Description: Available in various conjugation types.

IGF-I Receptor β Antibody

E90243 100ul
EUR 255
Description: Available in various conjugation types.

Phospho-IGF1 Receptor (Tyr1131/Tyr1146) Antibody

AF4397 100ul
EUR 350
Description: Human,Mouse,Rat,Pig

Phospho-IGF1 Receptor (Tyr1165/Tyr1166) Antibody

AF3123 100ul
EUR 280
Description: Human,Mouse,Rat

Phospho-IGF1 Receptor (Tyr1131/Tyr1146) Antibody

AF4397-100ul 100ul
EUR 350

Phospho-IGF1 Receptor (Tyr1131/Tyr1146) Antibody

AF4397-200ul 200ul
EUR 450

Phospho-IGF1 Receptor (Tyr1165/Tyr1166) Antibody

AF3123-100ul 100ul
EUR 280

Phospho-IGF1 Receptor (Tyr1165/Tyr1166) Antibody

AF3123-200ul 200ul
EUR 350

anti- IGF1 antibody

FNab09936 100µg
EUR 658.5
Description: Antibody raised against IGF1

anti- IGF1 antibody

LSMab09936 100 ug
EUR 463.2

Anti-Mannose 6 Phosphate Receptor (Cation independent)/IGF2R Antibody

A00951 100ug/vial
EUR 400.8

Anti-Mannose 6 Phosphate Receptor (Cation independent)/IGF2R Antibody

PA2182 100ug/vial
EUR 400.8

anti-IgE receptor antibody/ Rat anti- IgE receptor antibody ELIS

ELA-E0378r 96 Tests
EUR 1063.2

Human anti-IgE receptor antibody(anti-IgE receptor antibody)ELISA Kit

YLA0043HU-48T 48T
EUR 435

Human anti-IgE receptor antibody(anti-IgE receptor antibody)ELISA Kit

YLA0043HU-96T 96T
EUR 562.5

Insulin Like Growth Factor 2 Receptor (IGF2R) Antibody

20-abx104018
  • EUR 493.20
  • EUR 159.60
  • EUR 1378.80
  • EUR 678.00
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Insulin Like Growth Factor 2 Receptor (IGF2R) Antibody

20-abx104019
  • EUR 510.00
  • EUR 159.60
  • EUR 1412.40
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Insulin Like Growth Factor 2 Receptor (IGF2R) Antibody

20-abx104020
  • EUR 526.80
  • EUR 159.60
  • EUR 1479.60
  • EUR 710.40
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

20-abx172913
  • EUR 393.60
  • EUR 978.00
  • EUR 510.00
  • EUR 184.80
  • EUR 309.60
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

20-abx172914
  • EUR 1045.20
  • EUR 543.60
  • 1 mg
  • 200 ug

Insulin Like Growth Factor 2 Receptor (IGF2R) Antibody

20-abx172921
  • EUR 978.00
  • EUR 510.00
  • 1 mg
  • 200 ug

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

20-abx176960
  • EUR 1412.40
  • EUR 693.60
  • 1 mg
  • 200 ug

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

20-abx176961
  • EUR 1412.40
  • EUR 693.60
  • 1 mg
  • 200 ug

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

20-abx176962
  • EUR 1496.40
  • EUR 710.40
  • 1 mg
  • 200 ug

Insulin Like Growth Factor 2 Receptor (IGF2R) Antibody

20-abx212994
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Insulin Like Growth Factor 2 Receptor (IGF2R) Antibody

20-abx211941
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Insulin Like Growth Factor 2 Receptor (IGF2R) Antibody

20-abx325337
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

abx331540-100ul 100 ul
EUR 510

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

abx331990-100ul 100 ul
EUR 510

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

abx332030-100ul 100 ul
EUR 510

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

abx332058-100ul 100 ul
EUR 510

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

abx332126-100ul 100 ul
EUR 510

Insulin Like Growth Factor 2 Receptor (IGF2R) Antibody

20-abx326743
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

20-abx327081
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

20-abx113163
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Insulin Like Growth Factor 2 Receptor (IGF2R) Antibody

20-abx113166
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

abx016028-100ul 100 ul
EUR 493.2

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

abx033572-400ul 400 ul
EUR 627.6

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

abx033572-80l 80 µl
EUR 343.2

Insulin Like Growth Factor 2 Receptor (IGF2R) Antibody

abx038272-100ug 100 ug
EUR 469.2

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

20-abx128804
  • EUR 493.20
  • EUR 159.60
  • EUR 1378.80
  • EUR 678.00
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Insulin Like Growth Factor 2 Receptor (IGF2R) Antibody

20-abx125346
  • EUR 710.40
  • EUR 1028.40
  • EUR 493.20
  • 100 ul
  • 200 ul
  • 50 ul

Insulin Like Growth Factor 2 Receptor (IGF2R) Antibody

20-abx123245
  • EUR 493.20
  • EUR 710.40
  • 100 ul
  • 200 ul

Insulin Like Growth Factor 2 Receptor (IGF2R) Antibody

20-abx323556
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

20-abx327744
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

20-abx328731
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

20-abx009124
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

20-abx009125
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

20-abx000628
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

abx010963-100ul 100 ul
EUR 493.2

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

20-abx012900
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

20-abx306436
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

IGF1R Antibody / Insulin like growth factor 1 receptor

F54940-0.08ML 0.08 ml
EUR 140.25
Description: The IGF1 receptor binds insulin-like growth factor with a high affinity and plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. The protein possess tyrosine kinase activity.

IGF1R Antibody / Insulin like growth factor 1 receptor

F54940-0.4ML 0.4 ml
EUR 322.15
Description: The IGF1 receptor binds insulin-like growth factor with a high affinity and plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. The protein possess tyrosine kinase activity.

IGF1R Antibody / Insulin like growth factor 1 receptor

V8864-100UG 100ug
EUR 349.3
Description: Receptor tyrosine kinases (RTKs) are transmembrane molecular scaffolds that influence cellular processes including the cell cycle, cell migration, cell metabolism, cell survival, proliferation and differentiation. Insulin-like growth factor-I receptor (IGF-IR) is an RTK that stimulates growth in many different cell types, blocks apoptosis, acts as an intermediate of many growth hormone responses and may stimulate the growth of some types of cancer. The IGF-IR cognate ligand Insulin-like growth factor-I (IGF-I) promotes association of IGF-IR with Shc, GRB2 and Sos 1, which initiates Ras and ERK kinase cascades, thereby modifying transcription factor activity, such as activation of the Elk transcription factors. The modular phosphotyrosine binding (PTB) domains of Insulin receptor substrate (IRS)-1 and -2 can associate with active IGF-IR and initiate phosphatidylinositol 3-kinase-dependent downstream signals. The human IGF-IR gene maps to chromosome 15q26.3 and encodes a 1,376 amino acid precursor protein that cleaves into subunits. The human IGF-IIR gene maps to chromosome 6q26 and encodes a 2,491 amino acid transmembrane protein.

IGF1R Antibody / Insulin like growth factor 1 receptor

V8864-20UG 20ug
EUR 153.3
Description: Receptor tyrosine kinases (RTKs) are transmembrane molecular scaffolds that influence cellular processes including the cell cycle, cell migration, cell metabolism, cell survival, proliferation and differentiation. Insulin-like growth factor-I receptor (IGF-IR) is an RTK that stimulates growth in many different cell types, blocks apoptosis, acts as an intermediate of many growth hormone responses and may stimulate the growth of some types of cancer. The IGF-IR cognate ligand Insulin-like growth factor-I (IGF-I) promotes association of IGF-IR with Shc, GRB2 and Sos 1, which initiates Ras and ERK kinase cascades, thereby modifying transcription factor activity, such as activation of the Elk transcription factors. The modular phosphotyrosine binding (PTB) domains of Insulin receptor substrate (IRS)-1 and -2 can associate with active IGF-IR and initiate phosphatidylinositol 3-kinase-dependent downstream signals. The human IGF-IR gene maps to chromosome 15q26.3 and encodes a 1,376 amino acid precursor protein that cleaves into subunits. The human IGF-IIR gene maps to chromosome 6q26 and encodes a 2,491 amino acid transmembrane protein.

IGF1R Antibody / Insulin like growth factor 1 receptor

V8864SAF-100UG 100ug
EUR 349.3
Description: Receptor tyrosine kinases (RTKs) are transmembrane molecular scaffolds that influence cellular processes including the cell cycle, cell migration, cell metabolism, cell survival, proliferation and differentiation. Insulin-like growth factor-I receptor (IGF-IR) is an RTK that stimulates growth in many different cell types, blocks apoptosis, acts as an intermediate of many growth hormone responses and may stimulate the growth of some types of cancer. The IGF-IR cognate ligand Insulin-like growth factor-I (IGF-I) promotes association of IGF-IR with Shc, GRB2 and Sos 1, which initiates Ras and ERK kinase cascades, thereby modifying transcription factor activity, such as activation of the Elk transcription factors. The modular phosphotyrosine binding (PTB) domains of Insulin receptor substrate (IRS)-1 and -2 can associate with active IGF-IR and initiate phosphatidylinositol 3-kinase-dependent downstream signals. The human IGF-IR gene maps to chromosome 15q26.3 and encodes a 1,376 amino acid precursor protein that cleaves into subunits. The human IGF-IIR gene maps to chromosome 6q26 and encodes a 2,491 amino acid transmembrane protein.

Human Type I IGF receptor 16-13 (62 - 184) monoclonal antibody

MAC1 200 µg
EUR 358.8

Human Type I IGF receptor 24-55 (440 - 586) monoclonal antibody

MAD1 200 µg
EUR 358.8

Anti-IP Receptor antibody

STJ93743 200 µl
EUR 236.4
Description: Rabbit polyclonal to IP Receptor.

Anti-Ah Receptor antibody

STJ91510 200 µl
EUR 236.4
Description: Rabbit polyclonal to Ah Receptor.

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody (KLH)

20-abx133044
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody (RPE)

abx414062-100tests 100 tests
EUR 710.4

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody (HRP)

20-abx306437
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Anti-LDL Receptor Antibody

R1512-12 100ul
EUR 189
Description: LDLR (low density lipoprotein receptor) is a member of the LDL receptor gene family, which includes LDLR, LRP, Megalin, VLDLR, and ApoER2. The LDL receptor family is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats, and an O-linked sugar domain. The LDL receptor is a cell surface transmembrane protein that mediates the uptake of low density lipoprotein and its degradation in the lysosome, which provides cholesterol to cells. The cytoplasmic domain of the LDL receptor is necessary for the receptor to cluster in coated pits, which promotes the rapid endocytosis of bound LDL. Mutations in LDLR cause the autosomal dominant disease, familial hypercholesterolemia (FH), which promotes premature coronary atherosclerosis.

Anti-IP3 Receptor Antibody

ER1803-17 100ul
EUR 189
Description: Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.

Anti-EGF Receptor antibody

STJ99227 200 µl
EUR 236.4
Description: Mouse monoclonal to EGF Receptor.

Anti-EGF Receptor antibody

STJ99228 200 µl
EUR 236.4
Description: Mouse monoclonal to EGF Receptor.

Anti-EGF Receptor antibody

STJ99229 200 µl
EUR 236.4
Description: Mouse monoclonal to EGF Receptor.

Anti-EGF Receptor antibody

STJ99230 200 µl
EUR 236.4
Description: Mouse monoclonal to EGF Receptor.

Anti-VLDL Receptor Antibody

HA500194 100ul
EUR 189
Description: The very-low-density-lipoprotein receptor (VLDLR) is a transmembrane lipoprotein receptor of the low-density-lipoprotein (LDL) receptor family. VLDLR shows considerable homology with the members of this lineage. Discovered in 1992 by T. Yamamoto, VLDLR is widely distributed throughout the tissues of the body, including the heart, skeletal muscle, adipose tissue, and the brain, but is absent from the liver. This receptor has an important role in cholesterol uptake, metabolism of apolipoprotein E-containing triacylglycerol-rich lipoproteins, and neuronal migration in the developing brain. In humans, VLDLR is encoded by the VLDLR gene. Mutations of this gene may lead to a variety of symptoms and diseases, which include type I lissencephaly, cerebellar hypoplasia, and atherosclerosis.

Anti-GCSF Receptor Antibody

HA500282 100ul
EUR 189
Description: Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface. Mutations in CSF3R acquired in multipotent hematopoietic progenitor cells and resulting in truncated hyper-responsive forms of the receptor, have been identified in most cases of severe congenital neutropenia (SCN). Patients carrying these mutations are at risk for developing myelodysplastic syndromes and/or acute myeloid leukemia. Constitutive mutations leading to hyporesponsive forms of the receptor are responsible for the refractoriness to CSF3 treatment observed in some SCN patients.

Anti-GnRH receptor antibody

STJ16100834 100 µg
EUR 424.8

Anti-GnRH Receptor antibody

STJ16100836 100 µg
EUR 424.8

Anti-GHRH Receptor Antibody

E38A1470 100ug/100ul
EUR 225
Description: Available in various conjugation types.

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody Pair

abx117571-1pair5x96wellplates 1 pair (5x96 well plates)
EUR 1212

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody (FITC)

20-abx306438
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Anti-Renin Receptor antibody

STJ95413 200 µl
EUR 236.4
Description: Rabbit polyclonal to Renin Receptor.

anti- Secretin receptor antibody

FNab07697 100µg
EUR 658.5
Description: Antibody raised against Secretin receptor

anti- Oxytocin Receptor antibody

FNab06056 100µg
EUR 702
Description: Antibody raised against Oxytocin Receptor

anti- androgen receptor antibody

FNab00388 100µg
EUR 606.3
Description: Antibody raised against androgen receptor

Anti-Leptin Receptor antibody

STJ70931 100 µg
EUR 430.8

IGF-I Receptor (Phospho-Thr1163) Antibody

13068-100ul 100ul
EUR 302.4

IGF-I Receptor (Phospho-Thr1163) Antibody

13068-50ul 50ul
EUR 224.4

Human Type I IGF receptor 26-3 (283 - 440 or 586 - 908) monoclonal antibody

MAF1 200 µg
EUR 358.8

Anti-Ghrelin Receptor Antibody

A02127 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for Ghrelin Receptor Antibody (GHSR) detection. Tested with WB, IHC in Human, Rat, Mouse.

Anti-Mannose Receptor antibody

STJ16100193 100 µg
EUR 994.8

Anti-Mannose Receptor antibody

STJ16100194 50 µg
EUR 841.2

Anti-Glycine Receptor antibody

STJ120110 200 µg
EUR 631.2

Anti-Ghrelin Receptor antibody

STJ97575 200 µl
EUR 236.4
Description: Rabbit polyclonal to Ghrelin Receptor (A232).

Anti-Ghrelin Receptor Antibody

E38A9298 100ug/100ul
EUR 225
Description: Available in various conjugation types.

Insulin Like Growth Factor 1 Receptor (IGF1R) (pY1161) Antibody

20-abx134358
  • EUR 376.80
  • EUR 560.40
  • EUR 243.60
  • 100 ul
  • 200 ul
  • 30 ul

Insulin Like Growth Factor 1 Receptor (IGF1R) (pY1161) Antibody

20-abx133041
  • EUR 376.80
  • EUR 560.40
  • EUR 243.60
  • 100 ul
  • 200 ul
  • 30 ul

Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody (Biotin)

20-abx306439
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Insulin Like Growth Factor 1 Receptor (IGF1R) (pY1165 / 1166) Antibody

20-abx119382
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Human Anti-IgE Receptor Antibody (Anti-IgE Receptor) ELISA Kit

abx053524-96tests 96 tests
EUR 801.6

Mouse Anti-IgE Receptor Antibody (Anti-IgE Receptor) ELISA Kit

abx352484-96tests 96 tests
EUR 943.2

Anti-androgen receptor antibody

PAab00388 100 ug
EUR 426

Anti-androgen receptor antibody

PAab00389 100 ug
EUR 494.4

Anti-Oxytocin Receptor antibody

PAab06056 100 ug
EUR 494.4

Anti-Secretin receptor antibody

PAab07697 100 ug
EUR 463.2

Anti-Oxytocin Receptor Antibody

HA500203 100ul
EUR 189
Description: The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition.

Anti-Androgen Receptor Antibody

ER2001-34 100ul
EUR 189
Description: Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation . Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.9 Publications Isoform 3 and isoform 4 lack the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones.

Anti-Androgen receptor antibody

STJ180009 0.1 ml
EUR 356.4

The purpose of this study was to evaluate serum levels and IGF-2 binding protein IGFBP-3 and IGFBP-7 in patients with schizophrenia and the association of this protein with schizophrenia psychopathology and cognitive deficits